Aqueous hydrotrope solution as a safer medium for microwave enhanced hantzsch dihydropyridine ester synthesis
BM Khadilkar, VG Gaikar, AA Chitnavis
Index: Khadilkar, Bhushan M.; Gaikar, Vilas G.; Chitnavis, Ashish A. Tetrahedron Letters, 1995 , vol. 36, # 44 p. 8083 - 8086
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Citation Number: 130
Abstract
To a mixture of methyl 3-aminocrotonate (1.15g, 10mmol) and methyl acetoacetate (1.5mL, 14mmol) in a minimum amount of hydrotrope solution (5mL) in a round-bottom flask attached to a spiral condenser filled with chilled CCl 4 , was added 4-hydroxy- benzaldehyde (1.22g, 10mmol), and the mixture was subjected to microwave irradiation for 5 min to yield crystals of 1a (2.06g, 65 %), mp 199°C, after cooling the reaction mixture. ... Cookies are used by ...
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