1, 2, 5-thiadiazole derivatives are potent and selective ligands at human 5-HT 1A receptors

…, Y Palmer, DL Smith, TH Andree, LE Schechter

Index: Sabb, Annmarie L; Vogel, Robert L; Kelly, Michael G; Palmer, Yvette; Smith, Deborah L; Andree, Terrance H; Schechter, Lee E Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 8 p. 1069 - 1071

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Citation Number: 13

Abstract

Amino acid derivatives of 1,2,5-thiadiazol-3-yl-piperazine related to (+)-WAY-100135 and WAY-100635 are potent 5-HT 1A receptor agonists and antagonists, which have selective affinity for 5-HT 1A receptors versus α 1 and dopamine (D 2 , D 3 , and D 4 ) receptors. ... Amino acid derivatives of 1,2,5-thiadiazol-3-yl-piperazine related to (+)-WAY-100135 and WAY-100635 are potent 5-HT 1A receptor agonists and antagonists, which have selective affinity for human ...