Design and synthesis of novel derivatives of the muscarinic agonist tetra (ethylene glycol)(3-methoxy-1, 2, 5-thiadiazol-4-yl)[3-(1-methyl-1, 2, 5, 6-tetrahydropyrid-3-yl)- …

…, E Lawlor, M Warrier, WS Messer Jr

Index: Cao, Yang; Zhang, Minjia; Wu, Cindy; Lee, Selina; Wroblewski, Mary Elizabeth; Whipple, Trisha; Nagy, Peter I.; Takacs-Novak, Krisztina; Balazs, Attila; Toroes, Szilard; Messer Jr., William S. Journal of Medicinal Chemistry, 2003 , vol. 46, # 20 p. 4273 - 4286

Full Text: HTML

Citation Number: 17

Abstract

As part of a continuing effort to design and synthesize highly selective muscarinic agonists for different muscarinic receptor subtypes, several tetra (ethylene glycol)(3-methoxy-1, 2, 5- thiadiazol-4-yl)[3-(1-methyl-1, 2, 5, 6-tetrahydropyrid-3-yl)-1, 2, 5-thiadiazol-4-yl] ether (1) analogues were prepared and characterized. Different analogues were synthesized having hydrophilic spacers of di-, tri-, tetra-, penta (ethylene glycol) and tri (propylene glycol) ...