o-Iodoxybenzoic acid mediated oxidative condensation: synthesis of guanidines using 1,-3-disubstituted thiourea precursors

PS Dangate, KG Akamanchi

Index: Dangate, Prasad S.; Akamanchi, Krishnacharya G. Tetrahedron Letters, 2012 , vol. 53, # 50 p. 6765 - 6767

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Citation Number: 8

Abstract

Our research group is actively engaged in exploring the utility of hypervalent iodine reagents especially, o-iodoxybenzoic acid (IBX) and Dess-Martin periodinane (DMP). 19 Recently we have reported a mild and efficient oxidative desulfurization of 1,-3-disubstituted thioureas to carbodiimides 20a and synthesis of azoles 20b by using IBX in the presence of base such as triethylamine (TEA). As an extension to this, it was hypothesized that, a one pot synthesis of guanidine ...