Studies on the Synthesis of (2R, 4′ R, 8′ R)?螃窿?Tocopherol Alternative Syntheses of 2??Chroman??acetic Acid Intermediates

N Cohen, JW Scott, FT Bizzaro…

Index: Cohen; Scott; Bizzaro; et al. Helvetica Chimica Acta, 1978 , vol. 61, # 2 p. 837 - 843

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Citation Number: 12

Abstract

Abstract As an extension of previous studies on the total synthesis of (2R, 4′ R, 8′ R)-α- tocopherol (1)[1][2],(S)-(−)-2-(6-benzyloxy-2, 5, 7, 8-tetramethylchroman) acetic acid (6), a pivotal intermediate, possessing the absolute configuration required for construction of 1 was prepared by optical resolution of the racemic modification 11. the latter substance was obtained by two routes, one emanating from the hydroxy acetal 7 [1] and the other based ...