Synthesis and Anti-HCV Activity of 3', 5'-cyclic SATE Phosphonodiester Nucleoside as a Novel Prodrug

…, RS Seo, SW Yoo, J Choi, JH Hong

Index: Liu, Lian Jin; Seo, Rac Seok; Yoo, Seung Won; Choi, Jin; Hong, Joon Hee Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 4 p. 915 - 920

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Citation Number: 5

Abstract

Abstract A novel 2', 4'-dimethyl carbocyclic adenosine 5'-phosphonic acid analogue (20) was prepared using acyclic stereoselective route from commercially available 4- hydroxybutan-2-one (4). To improve cellular permeability and enhance the anti-HCV activity of this phosphonic acid, a 3', 5'-cyclic SATE phosphonodiester nucleoside prodrug (22) was prepared. The synthesized phosphonic nucleoside analogues,(20) and (22), were ...