A concise formal synthesis of alkaloid cryptotackiene and substituted 6 H-indolo [2, 3-b] quinolines
…, C Venkatesh, UK Syam Kumar, H Ila…
Index: Sundaram; Venkatesh; Syam Kumart; Ila; Junjappa Journal of Organic Chemistry, 2004 , vol. 69, # 17 p. 5760 - 5762
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Citation Number: 72
Abstract
A five-step formal synthesis of alkaloid cryptotackiene and its 2-formyl, 11-methyl/phenyl derivatives involving conjugate addition of enolate anion from cyclohexanone (or 4- methylcyclohexanone) to bis [(methylsulfanyl) methylene]-2-oxindole followed by heterocyclization in the presence of ammonium acetate as the key step has been developed. The 11-methylsulfanyl group in the initial precursor can be either desulfurized ...
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