Synthesis of α??Carbolines Starting from 2, 3??Dichloropyridines and Substituted Anilines
S Hostyn, G Van Baelen, GLF Lemiere…
Index: Hostyn, Steven; Van Baelen, Gitte; Lemiere, Guy L. F.; Maes, Bert U. W. Advanced Synthesis and Catalysis, 2008 , vol. 350, # 16 p. 2653 - 2660
Full Text: HTML
Citation Number: 49
Abstract
Abstract 9H-α-Carbolines have been prepared via consecutive intermolecular Buchwald– Hartwig reaction and Pd-catalyzed intramolecular direct arylation from commercially available 2, 3-dichloropyridines and substituted anilines. The combination of a high reaction temperature (180 C) and the use of DBU were found to be crucial for the intramolecular direct arylation reactions of the 3-chloro-N-phenylpyridin-2-amines as no reaction was ...
Related Articles:
An efficient synthesis of indoloquinoline alkaloid—neocryptolepine (cryptotackieine)
[Parvatkar, Prakash T.; Tilve, Santosh G. Tetrahedron Letters, 2011 , vol. 52, # 49 p. 6594 - 6596]
N-Bromosuccinimide as an efficient catalyst for the synthesis of indolo [2, 3-b] quinolines
[Ghorbani-Vaghei, Ramin; Malaekehpoor, Seyedeh Mina Tetrahedron Letters, 2012 , vol. 53, # 35 p. 4751 - 4753]
Efficient syntheses of the unknown quinolino [2, 3-c] cinnolines; synthesis of neocryptolepines
[Haddadin, Makhluf J.; Zerdan, Raghida M. Bou; Kurth, Mark J.; Fettinger, James C. Organic Letters, 2010 , vol. 12, # 23 p. 5502 - 5505]
[Peczynska-Czoch; Pognan; Kaczmarek; Boratynski Journal of Medicinal Chemistry, 1994 , vol. 37, # 21 p. 3503 - 3510]
A concise formal synthesis of alkaloid cryptotackiene and substituted 6 H-indolo [2, 3-b] quinolines
[Sundaram; Venkatesh; Syam Kumart; Ila; Junjappa Journal of Organic Chemistry, 2004 , vol. 69, # 17 p. 5760 - 5762]