Regiospecific Acylation, Alkylation, and Aldol Condensation using magnesium enolates resulting from the conjugate addition of grignard reagents to α, β??unsaturated …
F Näf, R Decorzant
Index: Naef,F.; Decorzant,R. Helvetica Chimica Acta, 1974 , vol. 57, p. 1317 - 1327
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Citation Number: 39
Abstract
Abstract The magnesium 3, 3-dimethylcyclohex-1-enolate 1i, formed in the copper catalyzed addition of methylmagnesium iodide to 3-methylcyclohex-2-enone, has been subjected to regiospecific electrophilic reactions such as acylation, alkylation, and aldol condensation in order to find a new access to the damascones, ionones and carotenoids. By way of illustration a new synthesis of γ-damascone is described.
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