The Journal of Organic Chemistry

. alpha.-Halocarbonyl compounds. II. Position-specific preparation of. alpha.-bromoketones by bromination of lithium enolates. Position-specific introduction of. alpha.,. …

PL Stotter, KA Hill

Index: Stotter,P.L.; Hill,K.A. Journal of Organic Chemistry, 1973 , vol. 38, # 14 p. 2576 - 2578

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Citation Number: 74

Abstract

Summary: Low-temperature bromination of specifically generated ketone enolates under aprotic conditions produces position-specific a-bromo ketones which can be converted to a,@-unsaturated ketones; no Favorskii rearrangement or other base-catalyzed side reactions and no positional equilibration of bromine are observed.