A Concise, High Yield Synthesis of the Selective ECE??Inhibitor, CGS 35066

AH Fauq, MA Khan, C Eckman

Index: Fauq, Abdul H.; Khan, Murad A.; Eckman, Christopher Synthetic Communications, 2004 , vol. 34, # 5 p. 775 - 782

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Citation Number: 6

Abstract

Abstract A highly efficient synthesis of the selective endothelin??converting enzyme, CGS 35066 is described. The key steps involved a Pd??catalyzed coupling of the phenyl rings of a diphenyl ether, and the use of the Schöllkopf reagent,(2 R)??2??isopropyl??3, 6??dimethoxy??2, 5?? dihydropyrazine as a chiral auxiliary furnishing a dibenzofuranylmethyl substituted amino ester in high (> 98%) enantiomeric purity, which was then carried forward to complete the ...