Aryloxyalkylamines, N-arylethylenediamines, and related compounds as anorectic agents

…, RS Shadbolt, GR Brown, A Ashford…

Index: Shadbolt; Sharpe; Brown; Ashford; Ross Journal of medicinal chemistry, 1971 , vol. 14, # 9 p. 836 - 842

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Abstract

Most'anorectic drugs have associated undesirable propert'ies such as CXS stimulation, euphoria, a, ddictiveness, and hypert'ension. A considerable number of modifications have been made to the amphetamine structure with a view to reducing it's stimulant properties while retaining anorexigenic activity. The most successful compound of this type is t, he N- ethyl-m-trifluoromethyl derivative, fenfluramine. 2 Some I-phenoxy-2-propylamine ...

Ligand-based design, synthesis, and biological evaluation of 2-aminopyrimidines, a novel series of receptor for advanced glycation end products (RAGE) inhibitors

[Han, Young Taek; Choi, Gyeong-In; Kim, Nam-Jung; Yun, Hwayoung; Lee, Sujin; Chang, Dong Jo; Lee, Jeewoo; Suh, Young-Ger; Son, Dohyun; Park, Hyun-Ju; Hong, Hyun-Seok; Kim, Hee; Ha, Hee-Jin; Kim, Young-Ho Journal of Medicinal Chemistry, 2012 , vol. 55, # 21 p. 9120 - 9135,16 Title/Abstract Full Text Show Details Han, Young Taek; Choi, Gyeong-In; Son, Dohyun; Kim, Nam-Jung; Yun, Hwayoung; Lee, Sujin; Chang, Dong Jo; Hong, Hyun-Seok; Kim, Hee; Ha, Hee-Jin; Kim, Young-Ho; Park, Hyun-Ju; Lee, Jeewoo; Suh, Young-Ger Journal of Medicinal Chemistry, 2012 , vol. 55, # 21 p. 9120 - 9135]

Ligand-based design, synthesis, and biological evaluation of 2-aminopyrimidines, a novel series of receptor for advanced glycation end products (RAGE) inhibitors

Preparation of substituted N-phenyl-4-aryl-2-pyrimidinamines as mediator release inhibitors

[Paul, Rolf; Hallett, William A.; Hanifin, John W.; Reich, Marvin F.; Johnson, Bernard D.; et al. Journal of Medicinal Chemistry, 1993 , vol. 36, # 19 p. 2716 - 2725]

Aryloxyalkylamines, N-arylethylenediamines, and related compounds as anorectic agents

Abstract

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