Preparation of substituted N-phenyl-4-aryl-2-pyrimidinamines as mediator release inhibitors
R Paul, WA Hallett, JW Hanifin, MF Reich…
Index: Paul, Rolf; Hallett, William A.; Hanifin, John W.; Reich, Marvin F.; Johnson, Bernard D.; et al. Journal of Medicinal Chemistry, 1993 , vol. 36, # 19 p. 2716 - 2725
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Citation Number: 46
Abstract
The general method of Bredereck'o was used for the synthesis of pyrimidines which involved reacting N, N-dimethylformamide dimethyl acetal (I), with an aromatic, generally heterocyclic, acetyl derivative 2, to give the enaminone 3. Reaction of 3 with a guanidine, 4, gave pyrimidinamine 5. At first, commercially available
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