Boron trifluoride-assisted perfluoroalkylation of carbon-nitrogen double bonds

…, S Okada, T Ono, Y Shiraishi, H Suzuki

Index: Uno, Hidemitsu; Okada, Shin-ichiro; Ono, Tetsushi; Shiraishi, Yasukazu; Suzuki, Hitomi Journal of Organic Chemistry, 1992 , vol. 57, # 5 p. 1504 - 1513

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Citation Number: 38

Abstract

In the presence of BF,. OEg,(perfluoroalky1) lithiums generated in situ from the reaction of primary perfluoroalkyl iodides and MeLi-LiBr reacted with imines, azines, and nitrones to afford perfluoroalkylated nitrogen-containing compounds in moderate to good yields. This method was successfully applied to the preparation of a (perfluoroalky1) glycine and optically active perfluoroalkylated amines.