2-Arylpyridines from 2-pyridylcopper/triphenylphosphine and iodoarenes

H Malmberg, M Nilsson

Index: Malmberg, Hans; Nilsson, Martin Tetrahedron, 1986 , vol. 42, # 14 p. 3981 - 3986

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Citation Number: 34

Abstract

2-Arylpyridines are formed rather selectively in 50 to 80% yields from 2-pyridylcopper and unactivated iodoarenes in the presence of one to two mol triphenylphosphine in toluene around 100° C. The selectivity may be due to the ability of the copper (I) iodide- triphenylphosphine complex as a leaving group or may be discussed in terms of oxidative addition/reductive elimination. The unsymmetric coupling reaction may be general since ...