Synthesis of some new substituted triazolo [4, 3-a][1, 4] benzodiazepine derivatives as potent anticonvulsants

B Narayana, KKV Raj, BV Ashalatha…

Index: Narayana; Vijaya Raj; Ashalatha; Kumari, N. Suchetha European Journal of Medicinal Chemistry, 2006 , vol. 41, # 3 p. 417 - 422

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Citation Number: 41

Abstract

Novel 8-chloro-6-(2-fluorophenyl)-1-(aryl)-4H-[1, 2, 4] triazolo [4, 3-a][1, 4] benzodiazepines (5a–f) were prepared by treating 7-chloro-5-(2-fluorophenyl)-1, 3-dihydro-2H-1, 4- benzodiazepine-2-thione with various aromatic acid hydrazides. The newly prepared compounds were characterized by spectral analysis. Compounds were tested for anticonvulsant activity. Four of the tested compounds such as 5a, 5d, 5e and 5f exhibited ...

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