An atom efficient and solvent-free synthesis of structurally diverse amides using microwaves
E Gelens, L Smeets, LAJM Sliedregt, BJ van Steen…
Index: Gelens, Edith; Smeets, Luc; Sliedregt, Leo A.J.M.; Van Steen, Bart J.; Kruse, Chris G.; Leurs, Rob; Orru, Romano V.A. Tetrahedron Letters, 2005 , vol. 46, # 21 p. 3751 - 3754
Full Text: HTML
Citation Number: 64
Abstract
An array of structurally diverse amides was synthesized efficiently by combining (primary and secondary) amines and carboxylic acids in one-pot under solvent-free microwave (MW) conditions. In most cases, no racemization was observed with optically active inputs and chiral amides were obtained in high ee or de.
Related Articles:
[Mei, Hui; Hu, Jianglin; Xiao, Se; Lei, Yizhu; Li, Guangxing Applied Catalysis A: General, 2014 , vol. 475, p. 40 - 47]
Chelate-assisted, palladium-catalyzed efficient carbonylation of aryl chlorides
[Ben-David, Yehoshua; Portnoy, Moshe; Milstein, David Journal of the American Chemical Society, 1989 , vol. 111, # 23 p. 8742 - 8744]
[Bhattacharya, Apurba; Plata, Robert Erik; Villarreal, Victor; Muramulla, Savitha; Wu, Jiejun Tetrahedron Letters, 2006 , vol. 47, # 4 p. 505 - 506]