Synthesis and Potent Tumour Necrosis Factor?螃? Production Inhibitory Activity of N??Pyridinylphthalimides and Derivatives

…, JM Robert, S ROBERT??PIESSARD…

Index: Collin; Robert; Robert-Piessard; Le Baut; Bobin-Dubigeon; Vernhet; Lang; Petit Pharmacy and Pharmacology Communications, 1998 , vol. 4, # 1 p. 27 - 31

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Abstract

Laboratoires de Chimie Organique et de Chimie The'rapeutique and *Laboratoire de Pharmacologie, Faculte' de Pharmacie, I rue Gaston Veil, 44035 Nantes, France ... Abstract A series of N-azaaryl(alky1)phthalimides incorporating amino(alky1)pyridines were synthe- sized and tested as inhibitors of TNF-a production. The most potent compounds were N-(4,6-dimethyl -pyridin-2-yl)tetrafluorophthalimide (8,40% inhibition at 10 PM), N-(3-methylpyridinyl)-5- ...

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