Tetrahedron: Asymmetry

Asymmetric hydrogenation of α-keto acid derivatives by rhodium-} amidophosphine-phosphinite {catalysts

JF Carpentier, A Mortreux

Index: Carpentier, Jean-Francois; Mortreux, Andre Tetrahedron Asymmetry, 1997 , vol. 8, # 7 p. 1083 - 1099

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Citation Number: 79

Abstract

The enantioselective hydrogenation of several α-keto esters (3a-f, 5a-j), α-keto amides (7a- e) and isatine derivatives (9a-d) with a set of four representative neutral homogeneous rhodium-amidophosphine-phosphinite catalysts has been investigated. Trifluoroacetato-Rh- AMPP catalytic precursors promoted the rapid, efficient synthesis of aliphatic α-hydroxy esters 4a-f in moderate to high enantioselectivities (66–95% ee), in contrast to most ...