Organic letters

Palladium-catalyzed dehydrative allylation of hypophosphorous acid with allylic alcohols

K Bravo-Altamirano, JL Montchamp

Index: Bravo-Altamirano, Karla; Montchamp, Jean-Luc Organic Letters, 2006 , vol. 8, # 18 p. 4169 - 4171

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Citation Number: 36

Abstract

A novel palladium-catalyzed allylation of H3PO2 with allylic alcohols is described. The phosphorus-carbon bond-forming reaction produces allylic-H-phosphinic acids and water, in the absence of additives. Primary H-phosphinic acids are obtained in excellent yields, whereas secondary H-phosphinic acids react sluggishly. A reusable polymer-supported catalyst is also described. The reaction provides an environmentally sound approach to H- ...

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