Facile and convenient strategy towards synthesis of 4-substituted 2-aminothiazolo [4, 5-d] pyridazinones

AA Thorave, PN Prajapati, JP Pethani, KC Kothari…

Index: Thorave, Amol A.; Prajapati, Pinkal N.; Pethani, Jignesh P.; Kothari, Krunal C.; Jain, Mukul R.; Patel, Pankaj R.; Kharul, Rajendra K. Tetrahedron Letters, 2009 , vol. 50, # 40 p. 5660 - 5663

Full Text: HTML

Citation Number: 2

Abstract

Convenient synthesis of 4-substituted 2-aminothiazolo [4, 5-d] pyridazinones has been achieved in 12 steps with overall yield of 19% by employing Grignard reaction as the key step. The route utilizes well established thiazole ring formation followed by Grignard reaction to introduce substitution at 4-position effectively. In addition to the use of inexpensive chemicals, the present route first time gave access to the 4-substituted 2-aminothiazolo [4, ...