Synthesis of UDP-glucose derivatives modified at the 3-OH as potential chain terminators of β-glucan biosynthesis
R Danac, L Ball, SJ Gurr, AJ Fairbanks
Index: Danac, Ramona; Ball, Lucy; Gurr, Sarah J.; Fairbanks, Antony J. Carbohydrate Research, 2008 , vol. 343, # 6 p. 1012 - 1022
Full Text: HTML
Citation Number: 19
Abstract
A series of UDP-d-glucose derivatives and precursors that have been modified at C-3 were synthesised from d-glucose as potential chain terminators of β-glucan biosynthesis. None of the UDP-derivatives or the precursors tested displayed significant anti-fungal activity in a series of germination assays on the dermatophyte Trichophyton rubrum.
Related Articles:
Development of carbohydrate-derived inhibitors of acid sphingomyelinase
[Roth, Anke G.; Redmer; Arenz, Christoph Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 2 p. 939 - 944]