Bioorganic & medicinal chemistry

Development of carbohydrate-derived inhibitors of acid sphingomyelinase

AG Roth, S Redmer, C Arenz

Index: Roth, Anke G.; Redmer; Arenz, Christoph Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 2 p. 939 - 944

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Citation Number: 13

Abstract

The acid sphingomyelinase is an emerging drug target, especially for inflammatory lung diseases. Presently, there are no directly-acting potent inhibitors available for cell-based studies. The potent inhibitor phosphatidylinositol-3, 5-bisphosphate (PtdIns3, 5P2) is not only unsuited for cell culture studies, but also does not provide hints for further structural improvements. In the SAR study described here, we replaced the inositolphosphate ...