Addition of lithiated methoxyallene to aziridines–a novel access to enantiopure piperidine and β-amino acid derivatives
V Prisyazhnyuk, M Jachan, I Brüdgam…
Index: Prisyazhnyuk, Vladimir; Jachan, Matthias; Bruedgam, Irene; Zimmer, Reinhold; Reissig, Hans-Ulrich Collection of Czechoslovak Chemical Communications, 2009 , vol. 74, # 7-8 p. 1069 - 1080
Full Text: HTML
Citation Number: 6
Abstract
Abstract Addition of lithiated methoxyallene to aziridine derivatives provided the expected primary addition products. The less substituted carbon of the aziridine ring was attacked selectively. The primary adducts could be converted to enantiopure piperidine derivatives or β-amino acid derivatives. The unexpected reactions lead to a tricyclic sulfonamide and to alkynyl-substituted aminoethers. The efficient two-step conversion of a piperidone ...
Related Articles:
[Moustafa, Mahmoud M. Abd Rabo; Pagenkopf, Brian L. Organic Letters, 2010 , vol. 12, # 14 p. 3168 - 3171]
Discovery of tetrahydropyrido [4, 3-d] pyrimidine derivatives for the treatment of neuropathic pain
[Sharma, Monika; Deekshith, Vanamala; Semwal, Arvind; Sriram, Dharmarajan; Yogeeswari, Perumal Bioorganic Chemistry, 2014 , vol. 52, p. 69 - 76]
[Yoo, Kyung Ho; Choi, Hyun Sik; Kim, Dong Chan; Shin, Kye Jung; Kim, Dong Jin; Song, Yun Seon; Jin, Changbae Archiv der Pharmazie, 2003 , vol. 336, # 4-5 p. 208 - 215]
[Yoo, Kyung Ho; Choi, Hyun Sik; Kim, Dong Chan; Shin, Kye Jung; Kim, Dong Jin; Song, Yun Seon; Jin, Changbae Archiv der Pharmazie, 2003 , vol. 336, # 4-5 p. 208 - 215]