Discovery of tetrahydropyrido [4, 3-d] pyrimidine derivatives for the treatment of neuropathic pain

…, V Deekshith, A Semwal, D Sriram, P Yogeeswari

Index: Sharma, Monika; Deekshith, Vanamala; Semwal, Arvind; Sriram, Dharmarajan; Yogeeswari, Perumal Bioorganic Chemistry, 2014 , vol. 52, p. 69 - 76

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Citation Number: 5

Abstract

Abstract A series of tetrahydropyridopyrimidine derivatives were synthesized and evaluated for neurotoxicity and peripheral analgesic activity followed by assessment of antiallodynic and antihyperalgesic potential in two peripheral neuropathic pain models, the chronic constriction injury (CCI) and partial sciatic nerve ligation (PSNL). Compounds (4b and 4d) exhibiting promising efficacies in four behavioral assays of allodynia and hyperalgesia ( ...