The Journal of Organic Chemistry

Reaction of 3, 3, 3-Trifluoropropylmagnesium Bromide with Carbonyl Compounds

GW Holbrook, OR Pierce

Index: Holbrook,G.W.; Pierce,O.R. Journal of Organic Chemistry, 1961 , vol. 26, p. 1037 - 1039

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Citation Number: 3

Abstract

The reaction of 3, 3, 3-trifluoropropylmagne~ ium bromide with methyl trifluoroacetate and 1, 1, 1, 5, 5, 5-hexafluoro-2-penta-none in both ether and tetrahydrofuran has shown the Grignard to be only a weak reducing agent. In the case of methyl trifluoroacetate, the principal product was a solid which on hydrolysis yielded the hydrate of 1, 1, 1, 5, 5, 5- hexafluoro-2-penta-none. Evidence for the structure of this solid intermediate, CFsCH&H& ...