Biologically active polycycloalkanes. 1. Antiviral adamantane derivatives
K Aigami, Y Inamoto, N Takaishi, K Hattori…
Index: Aigami,K. et al. Journal of Medicinal Chemistry, 1975 , vol. 18, p. 713 - 721
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Citation Number: 64
Abstract
Convenient methods for the synthesis of 1-substituted 3-adamantyl chlorides and bromides (2), 1-adamantylphenols and-cresols (3), and 1-adamantylacetic (6) as well as 1, 3- adamantanediacetic (11) acids are described. Several novel derivatives were synthesized from these key intermediates: adamantylcyclohexanols (4) and-cyclohexanones (5) from adamantylphenols (3), and esters (7, 12, and 22), amides (13 and la), thioamides (9 and ...
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