The Journal of organic chemistry

Short Access to 6-Substituted Pyrimidine Derivatives by the SRN1 Mechanism. Synthesis of 6-Substituted Uracils through a One-Pot Procedure

JI Bardagí, RA Rossi

Index: Bardagi, Javier I.; Rossi, Roberto A. Journal of Organic Chemistry, 2010 , vol. 75, # 15 p. 5271 - 5277

Full Text: HTML

Citation Number: 12

Abstract

The synthesis of 6-substituted 2, 4-dimethoxypyrimidines with different nucleophiles was accomplished with good to excellent yields (50− 95%) through SRN1 reactions, starting from commercially available 6-chloro-2, 4-dimethoxypyrimidine (1). Hydrolysis of these derivatives gave access to 6-substituted uracils with good yields and short times by the use of microwave irradiation. The preparation of uracils from 1 without the isolation of 2, 4- ...