Tandem Synthesis of 3-Chloro-4-iodoisoxazoles from 1-Copper (I) Alkynes, Dichloroformaldoxime, and Molecular Iodine
…, J Zhang, B Wang, Z Zhao, X Wang…
Index: Wang, Bo; Zhang, Jianlan; Wang, Xinyan; Liu, Nan; Chen, Wenwen; Hu, Yuefei Journal of Organic Chemistry, 2013 , vol. 78, # 20 p. 10519 - 10523
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Citation Number: 12
Abstract
A tandem synthesis for structurally novel 3-chloro-4-iodoisoxazoles was developed by simply mixing 1-copper (I) alkynes, dichloroformaldoxime, and molecular iodine together. The combination of 1-copper (I) alkyne and molecular iodine was well used as a synthetic equivalent of 1-iodoalkyne without the need for tedious preparation, purification, and storage of 1-iodoalkyne.
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