Synthesis of novel MPTP analogs as potential monoamine oxidase B (MAO-B) inhibitors
AS Kalgutkar, N Castagnoli Jr
Index: Kalgutkar, Amit S.; Castagnoli, Neal Journal of Medicinal Chemistry, 1992 , vol. 35, # 22 p. 4165 - 4174
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Citation Number: 37
Abstract
The nigrostriatal toxin l-methyl-l-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) is an excellent substrate and a weak inactivator of the flavoenzyme monoamine oxidase B (MAO-B). In an attempt to develop novel mechanism-based inactivators of MAO-B, we have synthesized analogs of MPTP bearing a variety of functional groups at either the N or the C (4) position and have examined their interactions with a purified MAO-B preparation isolated from beef ...
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