4-(Tetrazolylalkyl) piperidine-2-carboxylic acids. Potent and selective N-methyl-D-aspartic acid receptor antagonists with a short duration of action

PL Ornstein, DD Schoepp, MB Arnold…

Index: Ornstein, Paul L.; Schoepp, Darryle D.; Arnold, M. Brian; Leander, J. David; Lodge, David; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 90 - 97

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Citation Number: 79

Abstract

We have prepared a series of cis-4-(tetrazolylalkyl) piperidine-2-carboxylic acids as potent and selective N-methyl-paspartic acid (NMDA) receptor antagonists. NMDA antagonists may prove to be useful therapeutic agents, for instance, as anticonvulsants, in the treatment of neurodegenerative disorders such as Alzheimer's disease and in the prevention of neuronal damage that occurs during cerebral ischemia. The compounds prepared were evaluated ...