Design, synthesis and biological evaluation of some novel benzimidazole derivatives for their potential anticonvulsant activity

P Jain, PK Sharma, H Rajak, RS Pawar…

Index: Jain, Priyal; Sharma, Prakash Kumar; Rajak, Harish; Pawar, Rajesh Singh; Patil, Umesh Kumar; Singour, Pradeep Kumar Archives of Pharmacal Research, 2010 , vol. 33, # 7 p. 971 - 980

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Citation Number: 20

Abstract

Abstract Selective GABA A receptor ligands are widely used clinically to reduce the occurrence of convulsions. Hence there is an intense interest in developing new benzimidazole derivatives demonstrating high selectivity and high affinity for GABA A receptors. With the purpose of designing new chemical entities with an enhanced binding affinity for GABA A/BZd receptor complex, we carried out a QSAR study on benzotriazine ...