Synthesis of 2??(1??methyl??1, 2, 5, 6??tetrahydropyridin??3??yl) benzimidazoles
MH Jung, JM Park, IYC Lee…
Index: Jung, Myung Hee; Park, Jung Mee; Lee, Ihl-Young Choi; Ahn, Mija Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 1 p. 37 - 44
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Citation Number: 19
Abstract
Abstract A useful approach for the synthesis of pharmacologically active tetrahydropyridinylbenzimidazoles is described. 2-Pyridin-3-ylbenzimidazoles 3a-d have been synthesized by condensation of 3-pyridinecarbox-aldehyde 1 with substituted 1, 2- phenylenediamines 2a-d following oxidative cyclization with iodobenzene diacetate. Methylation of 3a-d with iodomethane and potassium hydroxide, subsequent formation of ...
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