Synthesis of heteroaromatic potential. beta.-adrenergic antagonists by the glycidol route

Y Antonio, C Camargo, E Galeazzi…

Index: Antonio,Y. et al. Journal of Medicinal Chemistry, 1978 , vol. 21, p. 123 - 126

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Citation Number: 5

Abstract

The synthesis of several 3-alkylamino-2-hydroxypropyl heteroaryl ethers (13-15, 17, and 18) is described. These compounds were prepared by the alkylamination of the corresponding glycidyl ethers (6-8, 10, and ll), which in turn were obtained from the requisite heteroaryl halides and the sodium salt of glycidol. The above basic ethers exhibited@-blocking activity, but the potency of the tested compounds was considerably less than that of propanolol.