Pd??Assisted Cross??Coupling Reactions with 4??Chlorocinnoline

…, G Vilkauskaite, W Holzer

Index: Heiter, Helmut Julian; Vilkauskaite, Gyte; Holzer, Wolfgang Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 1 p. 141 - 144

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Abstract

Abstract A series of 4-ethynylcinnolines 3a–e was prepared by Sonogashira reaction of 4- chlorocinnoline (1) with appropriate alkynes. Moreover, Suzuki coupling of 1 with boronic esters gave the corresponding 4-arylcinnolines 5a–c. Detailed NMR spectroscopic data including unambiguous chemical shift assignments of all 1 H, 13 C, and 15 N resonances of the obtained cinnoline derivatives are reported.