Kinetics and Mechanism of the Base??Catalysed Cyclisation of 2??(Substituted benzoylamino) benzamides Giving Quinazolin??4??one and Quinazolin??4??thione …

J Hanusek, M Sedlák, P Šimůnek…

Index: Hanusek, Jiri; Sedlak, Milos; Simunek, Petr; Sterba, Vojeslav European Journal of Organic Chemistry, 2002 , # 11 p. 1855 - 1863

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Citation Number: 5

Abstract

Abstract Acylation of 2-aminobenzamide and 2-(methylamino) benzamide with substituted benzoyl chlorides in acetone has been used to prepare the respective 2-(substituted benzoylamino) benzamides 1a− i, which were then subjected to sodium methoxide catalysed ring closure to give the respective 2-(substituted phenyl) quinazolin-4-ones 2a− i. The kinetics of the cyclisation reactions were monitored by UV/Vis spectroscopy at 25 C in ...