Continuous Flow Production of Thermally Unstable Intermediates in a Microreactor with Inline IR-Analysis: Controlled Vilsmeier–Haack Formylation of Electron-Rich …

…, R Becker, MME Delville, PJ Nieuwland…

Index: Van Den Broek, Sebastiaan A. M. W.; Leliveld, Jeroen R.; Becker, Rene; Delville, Marielle M. E.; Nieuwland, Pieter J.; Koch, Kaspar; Rutjes, Floris P. J. T. Organic Process Research and Development, 2012 , vol. 16, # 5 p. 934 - 938

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Citation Number: 26

Abstract

The Vilsmeier–Haack formylation of aromatic compounds is a well-established process in organic synthesis, largely driven by the fact that the resulting aldehydes are generally useful intermediates for the synthesis of fine chemicals and pharmaceutical products. Industrial- scale production, however, is often hampered by laborious procedures requiring the use of hazardous chemicals to produce the highly reactive intermediates. In order to circumvent ...