Preferential hydrogenation of aldehydes and ketones.

T Ohkuma, H Ooka, T Ikariya…

Index: Ohkuma, Takeshi; Ooka, Hirohito; Ikariya, Takao; Noyori, Ryoji Journal of the American Chemical Society, 1995 , vol. 117, # 41 p. 10417 - 10418

Full Text: HTML

Citation Number: 350

Abstract

Complex metal hydrides are among the most widely used reagents in organic synthesis.'NaBH4 is particularly appreciated because of its high chemoselectivity for conversion of aldehydes and ketones to alcohols, leaving olefinic or acetylenic bonds intact. Development of reliable hydrogenation catalysts with excellent carbonyl selectivity is highly desirable, especially for large-scale reactions for practical reasons. Most existing ...