Total synthesis of papulacandin D
…, CS Regens, T Kobayashi
Index: Denmark, Scott E.; Regens, Christopher S.; Kobayashi, Tetsuya Journal of the American Chemical Society, 2007 , vol. 129, # 10 p. 2774 - 2776
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Citation Number: 103
Abstract
A total synthesis of the antifungal agent papulacandin D is reported. The molecule is representative of a large class of C-aryl glycosides that exhibit significant antifungal activity. The synthetic strategy bifurcates the molecule into two nearly equal subunits, the arylglycoside and 18-carbon fatty acid side chain. The key strategic transformations are (1) the palladium catalyzed, organosilanolate-based cross-coupling of a protected glucal ...
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