Immuno??Polymeric Nanoparticles by Diels–Alder Chemistry

M Shi, JH Wosnick, K Ho, A Keating…

Index: Shi, Meng; Wosnick, Jordan H.; Ho, Karyn; Keating, Armand; Shoichet, Molly S. Angewandte Chemie - International Edition, 2007 , vol. 46, # 32 p. 6126 - 6131

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Citation Number: 83

Abstract

Immuno-nanoparticles hold great promise for targeted delivery of drugs, therapeutics, and diagnostics as numerous possible target receptors have been identified on the surface of cells in pathological conditions.[1–4] Under in vivo conditions, immuno-nanoparticles can deliver these agents to specific sites by both passive targeting, where a hydrophilic polymer outer layer such as polyethylene glycol (PEG) leads to longer circulation in the blood ...