Degradable self-assembling dendrons for gene delivery: experimental and theoretical insights into the barriers to cellular uptake

A Barnard, P Posocco, S Pricl, M Calderon…

Index: Barnard, Anna; Posocco, Paola; Pricl, Sabrina; Calderon, Marcelo; Haag, Rainer; Hwang, Mark E.; Shum, Victor W. T.; Pack, Daniel W.; Smith, David K. Journal of the American Chemical Society, 2011 , vol. 133, # 50 p. 20288 - 20300

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Citation Number: 115

Abstract

This paper uses a combined experimental and theoretical approach to gain unique insight into gene delivery. We report the synthesis and investigation of a new family of second- generation dendrons with four triamine surface ligands capable of binding to DNA, degradable aliphatic-ester dendritic scaffolds, and hydrophobic units at their focal points. Dendron self-assembly significantly enhances DNA binding as monitored by a range of ...