Tetrahedron Letters

Simultaneous dehalogenation and hydrogenation reduction of halogen-heteroaromatic aldehydes

XB Chen, QP Hu, QJ Yuan, W Ding, J Ren, BB Zeng

Index: Chen, Xi-Bo; Hu, Qiu-Peng; Yuan, Qian-Jia; Ding, Wei; Ren, Jiangmeng; Zeng, Bu-Bing Tetrahedron Letters, 2012 , vol. 53, # 29 p. 3798 - 3801

Full Text: HTML

Citation Number: 2

Abstract

Treatment of halogen-heteroaromatic aldehydes with catalytic amount of PdCl2 under atmosphere pressure of hydrogen in base medium (sodium acetate) leads to the corresponding dehalogenated primary alcohols. The reaction system was especially effective for the heteroaromatic compounds bearing aldehyde groups and halides (bromo-or chloro-functions).