A Platinum (II) Phenylphenanthroimidazole with an Extended Side??Chain Exhibits Slow Dissociation from ac??Kit G??Quadruplex Motif

…, J Fakhoury, MA Hancock, A Mittermaier…

Index: Castor, Katherine J.; Liu, Zhaomin; Fakhoury, Johans; Hancock, Mark A.; Mittermaier, Anthony; Moitessier, Nicolas; Sleiman, Hanadi F. Chemistry - A European Journal, 2013 , vol. 19, # 52 p. 17836 - 17845

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Citation Number: 13

Abstract

Abstract A series of three platinum (II) phenanthroimidazoles each containing a protonable side-chain appended from the phenyl moiety through copper (I)-catalyzed azide–alkyne cycloaddition (CuAAC) were evaluated for their capacities to bind to human telomere, c-Myc, and c-Kit derived G-quadruplexes. The side-chain has been optimized to enable a multivalent binding mode to G-quadruplex motifs, which would potentially result in ...