Aromatic analogues of DNA minor groove binders—synthesis and biological evaluation

…, K Bielawski, A Bielawska, K Midura-Nowaczek

Index: Puckowska, Anna; Bielawski, Krzysztof; Bielawska, Anna; Midura-Nowaczek, Krystyna European Journal of Medicinal Chemistry, 2004 , vol. 39, # 1 p. 99 - 105

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Citation Number: 21

Abstract

Nine carbocyclic analogues of mono-and bis-lexitropsins and two analogues of pentamidine with unsubstituted N-terminal amine group were synthesized. We have investigated the cytotoxic activity of new aromatic analogues of DNA binding ligands in MCF-7 breast cancer cells and assessed their ability to act as inhibitors of topoisomerase I and II. These studies indicate that aromatic analogues of bis-netropsin contain two identical units tethered by ...