The Journal of organic chemistry

Copper-catalyzed electrophilic amination of functionalized diarylzinc reagents

AM Berman, JS Johnson

Index: Berman, Ashley M.; Johnson, Jeffrey S. Journal of Organic Chemistry, 2005 , vol. 70, # 1 p. 364 - 366

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Citation Number: 59

Abstract

The copper-catalyzed electrophilic amination of functionalized diarylzinc reagents with O- acyl hydroxylamines allows for the preparation of functionalized tertiary arylamines in high yields, and is noteworthy for the mild reaction conditions employed. The functionalized diarylzinc reagents were prepared via an iodine/magnesium exchange of the corresponding aryl iodide followed by transmetalation of the resultant Grignard species with ZnCl2.

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