Tetrahedron Letters

Hybrids of macrolides and nucleobases or nucleosides

AM Costa, J Vilarrasa

Index: Costa, Anna M.; Vilarrasa, Jaume Tetrahedron Letters, 2000 , vol. 41, # 18 p. 3371 - 3375

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Citation Number: 10

Abstract

A few examples of hybrids/conjugates/chimeras of erythromycin A derivatives and nucleobases (uracil and thymine) or thymidine-derived nucleosides are reported. Linkers and reaction conditions have been investigated to avoid the degradation of the macrolide moiety (glycoside hydrolysis, ring cleavage, dehydration, etc.).