Naphthalimides exhibit in vitro antiproliferative and antiangiogenic activities by inhibiting both topoisomerase II (topo II) and receptor tyrosine kinases (RTKs)

X Wang, Z Chen, L Tong, S Tan, W Zhou, T Peng…

Index: Wang, Xin; Chen, Zhuo; Tong, Linjiang; Tan, Shaoying; Zhou, Wei; Peng, Ting; Han, Kun; Ding, Jian; Xie, Hua; Xu, Yufang European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 477 - 486

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Citation Number: 8

Abstract

Abstract Novel naphthalimide derivatives were designed and synthesized to modulate both topoisomerase II (topo II) and receptor tyrosine kinases (RTKs). Most target compounds exhibited effective and selective antiproliferative activities against three cancer cell lines by inhibiting topo II. The IC 50 values ranged from 1.5 to 19.1 μM. Moreover, compounds 8d and 12d moderately inhibited various angiogenesis-related RTKs, including FGFR1, ...