Total synthesis of the bacterial RNA polymerase inhibitor ripostatin B

F Glaus, KH Altmann

Index: Glaus, Florian; Altmann, Karl-Heinz Angewandte Chemie - International Edition, 2012 , vol. 51, # 14 p. 3405 - 3409

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Citation Number: 21

Abstract

The resistance of bacterial pathogens to antibiotic treatment has emerged as one of the central threats to public health in the 21st century.[1] At the same time, the surge of bacterial drug resistance has been paralleled by a decline in antibacterial drug discovery research in most of the pharmaceutical industry,[1, 2] a decline which has led to a general current paucity of agents (or the complete absence thereof) with satisfactory activity against major ...