Design, synthesis and biological evaluations of a novel series of enediynes constituted with DNA cleavage, alkylating and DNA binding agents via varies spacers
CF Lin, M Hwang, YH Kuo…
Index: Linb, Chi-Fong; Hwanga, Martin; Kuo, Yao-Haur; Wu, Ming-Jung Journal of the Chinese Chemical Society, 2007 , vol. 54, # 2 p. 525 - 532
Full Text: HTML
Citation Number: 0
Abstract
The antitumor antibiotics with enediyne cores show- ing either remarkable cytotoxicities or DNA cleaving prop- erties, and represented by neocarzinostatin,1 calicheamicins,2 esperimicins3 and dynemicins,4 have received the highest attention with design and synthesis of new leading com- pounds in the development of antitumor agents. The model of the DNA scission involved in the formation of ben- zenoid diradicals, which were generated from enediyne or ...
Related Articles:
A ring opening reaction of oxetanes with lithium acetylides promoted by boron trifluoride etherate
[Yamaguchi, Masahiko; Nobayashi, Yukio; Hirao, Ichiro Tetrahedron, 1984 , vol. 40, # 21 p. 4261 - 4266]
Preparation of carbocycles via base-catalyzed endo-mode cyclization of allenes
[Mukai, Chisato; Kuroda, Norikazu; Ukon, Rie; Itoh, Rumiko Journal of Organic Chemistry, 2005 , vol. 70, # 16 p. 6282 - 6290]
Preparation of carbocycles via base-catalyzed endo-mode cyclization of allenes
[Mukai, Chisato; Kuroda, Norikazu; Ukon, Rie; Itoh, Rumiko Journal of Organic Chemistry, 2005 , vol. 70, # 16 p. 6282 - 6290]