Total synthesis of U-71,184, s potent new antitumor agent modeled on cc-1065
MA Warpehoski
Index: Warpehoski, M.A. Tetrahedron Letters, 1986 , vol. 27, # 35 p. 4103 - 4106
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Citation Number: 56
Abstract
1 H NMR(DMSO-d 6 )δ: 1.4 (m, 1 H), 2.0 (s+m, 3H+1H), 3.2 (m. 1 H) 4.5 (m, 2H), 6.7 (s, 1 H), 6.9 (s, 1 H), 7.1–7.7 (m, 9H) 8.2 (brs, 1H), 10.3 (brs, 1H), 11.8 (brs, 1H), 11.9 (brs, 1H), [α] D + 155 (c=0.278, DMF). The CD curve of U-71.184 patterned that of CC-1065, supporting its absolute stereochemistry as shown. 1 H-NMR for 16 (pyridine -d 5 )δ: 13.2 (brs, 1H); 12.84(brs, 1H); 12.07(brs, 1H): 11.06(brs, 1H);8.93–8.64(m,2H + pyr.);8.13–7.25(m, 14H + pyr); 5.3(brs + ...
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